Incredible. In essence, more evidence of life forming from non-life. 2,3, or 4 reactions weren't found in these experiments, but 29, forming two biochemical pathways that formed necessary products from metabolic intermediates. It was always discussed that metabolism isn't really possible without RNA, a molecule that can form specific enzymes to catalyze metabolism, but the kicker is that the results of this experiment were shaped without the presence of RNA, but instead were catalyzed by metal ions. Not only does this answer a lot of questions, but it also makes the discourse of abiogenesis a lot more plausible with an important RNA backbone being formed from the Archean conditions. RNA --> metabolism --> life held a lot of problems, but metabolism --> RNA --> life makes a hell of a lot more sense.
Original published study in the journal Molecular Systems Biology here.
Reference: DOI 10.1002/msb.20145228 | Published online 25.04.2014 Molecular Systems Biology (2014) 10: 725
A blog dedicated to organizing all the types of things that capture my interest into one convenient location. Although it's not used with the intention of obtaining a loyal readership, if you feel that you're interested in the same thing, feel free to peruse at your disposal, and/or to contact me so we can be friends and learn from each other.
Showing posts with label Biochemistry. Show all posts
Showing posts with label Biochemistry. Show all posts
Sunday, November 1, 2015
Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons
Knockout or loss of function of STAT3 in mice increases the rewarding effects of running, in which case more voluntary running is observed in mice. Although the mechanism is not completely known yet, it is known that Leptin requires STAT3 for its function. This is what's behind pharmaceutical weight loss regimens, what's known as the "runner's high", and its hyperactivity in anorexia.
Original published study on the journal Cell Metabolism here.
Reference: DOI: http://dx.doi.org/10.1016/j.cmet.2015.08.003
Original published study on the journal Cell Metabolism here.
Reference: DOI: http://dx.doi.org/10.1016/j.cmet.2015.08.003
Tweaking Mitochondria via Nutrition
Neurological Effects of Taurine
Hippocampal neurogenesis and lowered arterial stress (and much more). Taurine's benefits to the human body are revolutionary.
Life Extension magazine article here.
Life Extension magazine article here.
Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities
mtDNA deletion mutations are causal in sarcopenia, and are concomitant with electron transport chain abnormalities, causing apoptotic mechanisms to activate, and cell necrosis.
Original published study on the journal Aging Cell here.
Reference: DOI: 10.1111/acel.12399
Original published study on the journal Aging Cell here.
Reference: DOI: 10.1111/acel.12399
Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
First direct evidence of Leptin-driven lipolysis through sympathetic neuron innervations from the hypothalamus within fat cells. Implications would include future pharmacological treatments for obesity.
Article by The Scientist here.
Original published study on the journal Cell here.
Reference: DOI: http://dx.doi.org/10.1016/j.cell.2015.08.055
Leptin on Wiki
Article by The Scientist here.
Original published study on the journal Cell here.
Reference: DOI: http://dx.doi.org/10.1016/j.cell.2015.08.055
Leptin on Wiki
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