Knockout or loss of function of STAT3 in mice increases the rewarding effects of running, in which case more voluntary running is observed in mice. Although the mechanism is not completely known yet, it is known that Leptin requires STAT3 for its function. This is what's behind pharmaceutical weight loss regimens, what's known as the "runner's high", and its hyperactivity in anorexia.
Original published study on the journal Cell Metabolism here.
Reference: DOI: http://dx.doi.org/10.1016/j.cmet.2015.08.003
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